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KMID : 1214920190250020104
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Soonchunhyang Medical Science
2019 Volume.25 No. 2 p.104 ~ p.109
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Increased Effect-Site Concentration of Propofol Reduces EC50 of Remifentanil for Successful Intubation Using the Shikani Optical Stylet without Neuromuscular Blockade
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Cho Sang-Yun
Lee Chang-Wook
Park Hyung-Joon
Park Seong-Ho
Jeon Woo-Jae
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Abstract
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Objective: For short-duration surgery, propofol and remifentanil are the drugs of choice for intubation without neuromuscular blockade. The Shikani Optical Stylet (SOS) is a novel semi-rigid type fiberoptic laryngoscope. In this study, we determined the clinically required effect-site concentration of remifentanil for intubation using SOS without neuromuscular blockade depending on propofol effect-site concentration.
Method: We enrolled patients scheduled for elective surgery with general anesthesia, and assigned them into two groups by a randomized, double-blind method: concentration of propofol 3.5 μg/mL (group PRO 3.5) and 7.0 μg/mL (group PRO 7.0). Anesthesia was conducted with target-controlled infusion in predetermined target effect-site concentrations of propofol. The concentration of remifentanil for successful intubation using SOS in 50% of patients (EC50) was determined using a modified Dixon’s up-anddown method.
Results: The mean± standard deviation EC50 of remifentanil was 5.07± 0.40 ng/mL in group PRO 3.5 and 1.79± 0.44 ng/mL in group PRO 7.0. From probit analysis, EC50 and EC95 of remifentanil in group PRO 3.5 were 4.85 ng/mL (95% confidence interval [CI], 4.44?5.16 ng/mL) and 5.42 ng/mL (95% CI, 5.13?7.47 ng/mL) respectively, and EC50 and EC95 of remifentanil in group PRO 7.0 were 1.68 ng/mL (95% CI, 1.22?2.01 ng/mL) and 2.29 ng/mL (95% CI, 1.98?4.05 ng/mL), respectively.
Conclusion: Increased concentration of propofol reduced EC50 of remifentanil for successful intubation using SOS without neuromuscular blockade.
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KEYWORD
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Propofol, Remifentanil, Intubation
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